目的：探討Co Q10的補充是否能抑制運動誘發的脂質過氧化、肌肉的損傷及有氧運動表現的影響。方法：16名女性足球員受試者，分Co Q10組(120 mg/day)及安慰劑等兩組，雙盲實驗設計，進行為期四週的補充。受試者進行兩階段運動負荷測試：先於65% VO(下標 2max)運動負荷進行60分鐘運動後，接連90% VO(下標 2max)負荷跑至力竭為止。結果：顯示Co Q10補充組和安慰劑組比較，運動後脂質過氧化物丙二醛(malondialdehyde, MDA)濃度並未因Co Q10補充而改善(p>.05)，運動後肌酸激酶(creatine kinase, CK)增加幅度百分比兩組間並無顯著性差異(p>.05)。結論：這次試驗我們無法支持Co Q10補充可以有效地抑制運動後脂質過氧化產物MDA濃度上升，及降低肌肉損傷指標CK濃度的說法，維持四週CoQ10的補充亦不會明顯增進有氧運動表現，包括最大攝氧量(VO(下標 2max))、最大心跳率(HRmax)、呼吸交換率(respiratory exchange ratio, RER)及運動至力竭時間。

Purpose: this study was to examine whether supplementation of Co Q10 could lower formation of lipid peroxides, muscular damage, and aerobic exercise performance in athletes. Methods: Sixteen female soccer players were assigned to either the Co Q10 (120 mg per day) group or to the placebo group by matching their maximal oxygen uptakes (VO(subscript 2max)). Sixty minutes of endurance exercise at 65% VO(subscript 2max) followed by exercise at 90% VO(subscript 2max) until exhaustion was performed on a treadmill before and after a 4-week treatment period. The administration of either Co Q10 or placebo and the conduction of exercise tests were done double blinded. Results: there were no difference of malondialdehyde (MDA) after exercise between Co Q10 and placebo groups (p>.05). There were also no significant difference of increased percentage in creatine kinase (CK) after exercise between Co Q10 and placebo groups (p<.05). Conclusions: the results could not prove directly that Co Q10 supplementation might suppress the increase of lipid peroxides during exercise, and showed a trend of reduce creatine kinase, an index of muscular damage. The results indicated that four weeks Co Q10 supplementation did not affect aerobic exercise indices such as maximal heart rate, maximal oxygen consumption, respiratory exchange ratio, and time to exhaustion.

Co Q10; 抗氧化效力; 有氧運動表現; 脂質過氧化物

Co Q10; antioxidant effect; aerobic exercise performance; lipid peroxides