肥胖和身體缺乏活動為加速老化與相關疾病罹患的主要因素。而研究指出熱量限制和運動在延緩老化與提昇壽命上，可做為抗老化的有效策略。不同物種中進行熱量限制與運動實驗，如齧齒動物、恆河猴及人類，均能產生延緩老化的生理適應現象，包括能量代謝調控、體脂肪減少及胰島素敏感度提昇等。然而，運動與最大壽命的關連仍未釐清，但對提昇生活品質與預防慢性病是不爭的事實。另外，體溫和胰島素濃度下降及DHEA-s增加可視為老化的預測指標，未來人體的健康促進上具應用價值。

Obesity and inactivity are main determinants of accelerating aging and increasing age-related chronic disease. Inversely, calorie restriction and exercise on retarding aging and extend life span are probably an effective antiaging strategies for human. Calorie restriction and exercise, which the beneficial effects of retarding aging, affected energy metabolisms, decreased body fat, and improved insulin sensitivity in a variety of species, including rats, mice, rhesus monkey, and humans. Even if the relationship between exercise and maximum life span is unknown, exercise can improve the quality of life and prevent the onset of chronic disease undeniably. Furthermore, the fact that calorie restriction and exercise exhibit reduced insulin, body temperature, and decline in DHEA-s may as predictors on retard aging for humans in the future.

熱量限制; 運動; 老化

Calorie restriction; Exercise; Aging