The purpose of the study was to investigate the effects of stimulus changes on orienting reflex (OR) and the relationship between two indexes of heart rate (HR). Seventy-eight undergraduate students, with a mean age of 21 years old, participated in this experiment. All subjects were given 32 standard stimuli (SS) and 4 interpolated test stimuli (TS). The SS for all subjects were a meaningless oral word (verbal stimulus, VS) and a circle (figure stimulus, FS). The TS for Group One, the control group, was the same as the SS. The TS for Group Two was the title of the subject's department (VS) and an ellipse (FS). For Group Three, the TS was the subject's name (VS) and a tringle (FS). The results of the study were as follows: (1) There was no group difference in the magnitude of OR to the changes of verbal and figure stimulus. (2) As a rule, the magnitude of OR evoked by verbal stimulus was greater than by figure stimulus. (3) There was no significant relationship between two indexes of HR.