Objectives: Chronic fatigue is one of the most common symptoms in medical care. This investigation is to explore the comorbidity of somatic & psychiatric symptoms and personality characteristic of patients. Methods: 102 patients with chronic fatigue and 70 healthy controls were evaluated by self-reported questionnaire. Results: Those with chronic fatigue had a higher prevalence of psychiatric diseases(p＜0.00l), sleep disturbance(p＜0.001), immune impairment (p＜0.01), and peptic ulcer(p＜0.05). The amount of psychosomatic symptoms of patients was significantly more than the control group(12.13±6.36 vs. 3.03±3.63, p＜0.001). There were more than half of the patients suffering from mouth dryness, neck tightness, poor memory, palpitation, headache or dizziness, eye dryness or blurred vision, irritability and poor concentration. The personality of patients showed more suspiciousness, sensitivity, and radicalism (p＜0.05). Conclusions: The symptoms of chronic fatigue patients frequently covered multiple organs without clear underlying medical explanations and related with psychological factors. Clinicians should approach chronic fatigue patients with a bio-psychosocial mode, intervening in patient’s psychosocial variables as well as biological variables.

慢性疲勞；機能性身體化症候群；生理心理社會模式

chronic fatigue; functional somatic syndrome; bio-psycho-social model